Health management of horses under high challenge from trypanosomes: A case study from Serengeti, Tanzania
- 作者：Harriet Auty ; Alison Mundy ; Robert D. Fyumagwa ; Kim Picozzi ; Susan Welburn ; Richard Hoare
- 关键词：Bovine ; Calves ; Colostrum ; Immunity ; Leukocyte
- 刊名：Veterinary Parasitology
- 出版年：2008
- 期刊代码：107_03044017
- 类别：abs
- 出版时间：4 July 2008
- 卷：154
- 期：3-4
- 页码：233-241
- 文件大小：551 K
摘要
Although it has been established that maternal leukocytes traffic from colostrum into the neonatal circulation, the effects of these cells on neonatal immunity are only beginning to be understood. This study examined the effects of maternal colostral leukocytes on development and maturation of neonatal antigen presenting cells. At birth, groups of neonatal calves received whole or cell-free colostrum (CFC) from their respective dams. Peripheral blood samples were obtained over the first 4 weeks of life, and expression of surface markers associated with cellular activation and physiological stress were monitored on monocyte lineage cells. Calves receiving cell-free colostrum at birth expressed elevated levels of CD11a, CD11c, and CD14, compared to calves receiving whole colostrum (C). Calves receiving cell-free colostrum had an elevated number of monocytes in the peripheral blood during the first 2 weeks of life, however, these cells expressed lower levels of expression of CD25 and MHC class I compared to calves receiving whole colostrum. The most significant differences in marker expression occurred within the first 7 days of life.