Accuracy of multi-slice computed tomography for measurement of left ventricular ejection fraction compared with cardiac magnetic resonance imaging and two-dimensional transthoracic echocardiography: A systematic review and meta-analysis

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• 作者：Camilla Asferg^a ; ^{C.asferg@gmail.com} ; Lotte Usinger^a ; ¹ ; ^{Lotusi01@glo.regionh.dk} ; Thomas S. Kristensen^b ; ³ ; ^{Tskaarup@yahoo.com} ; Jawdat Abdulla^a ; ² ; ^{jawab@dadlnet.dk}
• 关键词：CAD ; coronary artery disease ; CI ; confidence interval ; CT ; computed tomography ; HF ; heart failure ; IHD ; ischemic heart disease ; LVEF ; left ventricular ejection fraction ; MRI ; magnetic resonance imaging ; MSCT ; multi-slice computed tomography ; SD ; standard
• 刊名：European Journal of Radiology
• 出版年：2012
• 期刊代码：93_0720048x
• 类别：med
• 出版时间：May, 2012
• 卷：81
• 期：5
• 页码：e757-e762
• 文件大小：583 K

摘要

ass="h4">Background

Multi-slice computed tomography (MSCT) allows non-invasive assessment of the coronary arteries and simultaneously can provide measurement of left ventricular ejection fraction (LVEF). The accuracy of newer MSCT generations (64-slice or more) for assessment of LVEF compared with magnetic resonance imaging (MRI) and two-dimensional transthoracic echocardiography (TTE) has not been evaluated in a meta-analysis.

ass="h4">Purpose

To evaluate, via a systematic literature review and meta-analysis, whether MSCT can assess LVEF with high accuracy compared with MRI and TTE.

ass="h4">Methods

Electronic databases and reference lists for relevant published studies were searched. Twenty-seven eligible studies provided mean LVEF%with its standard deviation (SD) measured by MSCT versus MRI and TTE. Meta-analysis of weighted mean difference (WMD) and Bland-Altman method were used to quantify the mean difference and agreement between MSCT compared with MRI and TTE.

ass="h4">Results

The results of combining 12 studies showed no significant difference in LVEF%between MSCT and MRI with a WMD of 鈭?.11 (鈭?.48, 1.26, 95%CI), p = 0.88. Bland-Altman analysis showed excellent agreement between MSCT and MRI with a bias of 0.0 (鈭?.7, 3.7 卤 1.96SD) with 95%CI. The results of combining 15 studies showed no significant difference in LVEF between MSCT versus TTE measurements with a WMD of 0.19 (鈭?.13 to 1.50; 95%CI), p = 0.87. Bland-Altman analysis showed excellent agreement between MSCT and TTE with a bias of 0.3 (鈭?.7, 5.7 卤 1.96SD) with 95%CI.

ass="h4">Conclusion

The newer MSCT generations can provide accurate LVEF measurement compared to MRI and TTE. MSCT represents a valid technique for the combined evaluation of LVEF and coronary artery disease.