To evaluate, via a systematic literature review and meta-analysis, whether MSCT can assess LVEF with high accuracy compared with MRI and TTE.
Electronic databases and reference lists for relevant published studies were searched. Twenty-seven eligible studies provided mean LVEF%with its standard deviation (SD) measured by MSCT versus MRI and TTE. Meta-analysis of weighted mean difference (WMD) and Bland-Altman method were used to quantify the mean difference and agreement between MSCT compared with MRI and TTE.
The results of combining 12 studies showed no significant difference in LVEF%between MSCT and MRI with a WMD of 鈭?.11 (鈭?.48, 1.26, 95%CI), p = 0.88. Bland-Altman analysis showed excellent agreement between MSCT and MRI with a bias of 0.0 (鈭?.7, 3.7 卤 1.96SD) with 95%CI. The results of combining 15 studies showed no significant difference in LVEF between MSCT versus TTE measurements with a WMD of 0.19 (鈭?.13 to 1.50; 95%CI), p = 0.87. Bland-Altman analysis showed excellent agreement between MSCT and TTE with a bias of 0.3 (鈭?.7, 5.7 卤 1.96SD) with 95%CI.
The newer MSCT generations can provide accurate LVEF measurement compared to MRI and TTE. MSCT represents a valid technique for the combined evaluation of LVEF and coronary artery disease.