• 作者：B. Puerto-Herná ; ndez^a ; ^{beapuertoh@hotmail.com} ; G. Rebolleda^a ; J.L. Garcí ; a-Pé ; rez^a ; F.J. Muñ ; oz-Negrete^a ; C. Gonzá ; lez-Gordaliza^b
• 关键词：Ecografí ; a doppler color ; Flujo sanguí ; neo ocular ; Combigan&reg ; Arteria central de la retina ; Arteria oftá ; lmica ; Í ; ndice de resistencia
• 刊名：Archivos de la Sociedad Espa帽ola de Oftalmolog铆a
• 出版年：2011
• 期刊代码：pca66_03656691
• 类别：med
• 出版时间：February 2011
• 卷：86
• 期：2
• 页码：42-46
• 文件大小：127 K

Purpose

This study was undertaken to compare the ocular haemodynamic effects of Combigan^庐 versus placebo in patients with ocular hypertension (OHT).

Methods

Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan^庐 and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging(CDI) ultrasound, concurrently with intraocular pressure (IOP).

Results

Combigan^庐 significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan庐 showed a statistically significant decrease in CRA resistive index (P = 0.007).

Conclusions

Patients treated for 3 months with Combigan^庐 showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP.