Cognitive control links alcohol use, trait disinhibition, and reduced cognitive capacity: Evidence for medial prefrontal cortex dysregulation during reward-seeking behavior

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• 作者：Tim Bogg^a ; ^b ; ^{tdbogg@gmail.com} ; Rena Fukunaga^b ; Peter R. Finn^b ; Joshua W. Brown^b
• 关键词：Alcohol ; Disinhibition ; IQ ; Cognitive control ; mPFC ; fMRI
• 刊名：Drug and Alcohol Dependence
• 出版年：2012
• 期刊代码：81_03768716
• 类别：med
• 出版时间：1 April, 2012
• 卷：122
• 期：1-2
• 页码：112-118
• 文件大小：825 K

摘要

Background

Guided by the prediction of response-outcome theory of cognitive control (), the present study examined reward-seeking medial prefrontal cortex (mPFC) activity as a common neuro-functional marker of excessive alcohol consumption, trait disinhibition, and reduced cognitive capacity; all of which have shown consistent patterns of covariation in previous psychometric research (e.g., ).

Methods

A sample of 18-23-year-old university students with a heterogeneous prevalence of alcohol dependence was assessed with functional magnetic resonance imaging (fMRI) while completing a version of the Balloon Analogue Risk Task (). A follow-back typical weekly alcohol consumption interview, self-report measures of trait disinhibition and IQ, and a complex span working memory task also were administered.

Results

Correlational region-of-interest analyses showed greater typical weekly alcohol consumption, greater trait disinhibition, and lower IQ were associated with greater reductions in mPFC activity during reward-seeking behaviors (successive inflation choices). The results also showed greater typical weekly alcohol consumption, greater trait disinhibition, and lower IQ were associated with greater increases in mPFC activity during reward-seeking outcomes (successive successful inflation outcomes). No significant relations with the measure of working memory were found.

Conclusions

The findings suggest mPFC activity during risk/reward appraisal and performance monitoring is a common neuro-functional feature of co-varying expressions of excessive alcohol consumption, trait disinhibition, and lower IQ.