Synthesis, structures and urease inhibition studies of copper(II) and nickel(II) complexes with bidentate N,O-donor Schiff base ligands

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• 作者：Xiongwei Dong^a ; Yuguang Li^a ; ^b ; ^{liyg2010@wtu.edu.cn} ; Zuowen Li^a ; Yongming Cui^a ; Hailiang Zhu^b ;
• 关键词：Copper(II) complexes ; Schiff base ligands ; X-ray structure ; Urease inhibitors ; Molecular docking
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2012
• 期刊代码：53_01620134
• 类别：ch
• 出版时间：March, 2012
• 卷：108
• 期：Complete
• 页码：22-29
• 文件大小：1024 K

摘要

Five mononuclear copper(II) and nickel(II) complexes of Schiff base ligands derived from 4-hydroxyphenethylamine and 2-phenylethylamine were synthesized and determined by single crystal X-ray analysis. The crystal structures of these complexes presented the square planar coordination geometry at the metal center. The inhibitory activity of all the obtained complexes was tested in vitro against jack bean urease. It was found that Schiff base copper(II) complexes, namely [Cu(C₁₅H₁₃BrNO₂)₂]路2(C₆H₇N) (1), [Cu(C₁₅H₁₂Br₂NO₂)₂]路2(DMF) (2), Cu(C₁₉H₁₆NO₂)₂ (3) and Cu(C₁₉H₁₆NO)₂ (5), showed strong inhibitory activity against jack bean urease (IC₅₀ = 1.45-3.59 渭M), while Schiff base nickel(II) complex, [Ni(C₁₉H₁₆NO₂)₂]路2(DMF) (4), exhibited weak inhibitory activity (IC₅₀ > 50 渭M). Their structure-activity relationships were further discussed.