Synthesis, spectral characterization, DNA binding ability and antibacterial screening of copper(II) complexes of symmetrical NOON tetradentate Schiff bases bearing different bridges

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• 作者：Saleh O. Bahaffi^a ; Ayman A. Abdel Aziz^a ; ^b ; ^{aymanaziz31@gmail.com} ; ^{aabdelaziz@ut.edu.sa} ; Maher M. El-Naggar^a
• 关键词：Synthesis ; Cu(II) complexes ; NOON donors ; Characterization ; CT-DNA binding ; Antibacterial screening
• 刊名：Journal of Molecular Structure
• 出版年：2012
• 期刊代码：62_00222860
• 类别：ch
• 出版时间：8 August, 2012
• 卷：1020
• 期：Complete
• 页码：188-196
• 文件大小：926 K

摘要

A novel series of four copper(II) complexes were synthesized by thermal reaction of copper acetate salt with symmetrical tetradentate Schiff bases, N,N鈥瞓is(o-vanillin)4,5-dimethyl-l,2-phenylenediamine (H₂L¹), N,N鈥瞓is(salicylaldehyde)4,5-dimethyl-1,2-phenylenediamine (H₂L²), N,N鈥瞓is(o-vanillin)4,5-dichloro-1,2-phenylenediamine (H₂L³) and N,N鈥瞓is(salicylaldehyde)4,5-dichloro-1,2-phenylenediamine (H₂L⁴), respectively. All the new synthesized complexes were characterized by using of microanalysis, FT-IR, UV-Vis, magnetic measurements, ESR, and conductance measurements, respectively. The data revealed that all the Schiff bases (H₂L^1-4) coordinate in their deprotonated forms and behave as tetradentate NOON coordinated ligands. Moreover, their copper(II) complexes have square planar geometry with general formula [CuL^1-4]. The binding of the complexes with calf thymus DNA (CT-DNA) was investigated by UV-Vis spectrophotometry, fluorescence quenching and viscosity measurements. The results indicated that the complexes bind to CT-DNA through an intercalative mode. From the biological activity view, the copper(II) complexes and their parent ligands were screened for their in vitro antibacterial activity against the bacterial species Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosai by well diffusion method. The complexes showed an increased activity in comparison to some standard drugs.