(E)-3-(2-(furan-ylmethylene)hydrazinyl)-3-oxo-N-(thiazol-2yl)propanamide complexes: Synthesis, characterization and antimicrobial studies

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• 作者：M.N. Abd El-Hady ; R.R. Zaky ; ^{rania.zaky@yahoo.com} ; K.M. Ibrahim ; E.A. Gomaa
• 关键词：A. Hydrazone complexes ; B. Spectral studies ; C. Thermal analysis ; D. Antimicrobial activity
• 刊名：Journal of Molecular Structure
• 出版年：2012
• 期刊代码：62_00222860
• 类别：ch
• 出版时间：30 May, 2012
• 卷：1016
• 期：Complete
• 页码：169-180
• 文件大小：680 K

摘要

Schiff base complexes of Co(II), Ni(II), Cu(II), Pd(II), Cd(II), Hg(II), Zn(II) and U(VI)O₂ (E)-3-(2-(furan-ylmethylene)hydrazinyl)-3-oxo-N-(thiazol-2yl)propanamide (H₂FH) containing N and O donor sites have been synthesized. Both ligand and its metal complexes were characterized by different physicochemical methods, elemental analysis, molar conductivity, (¹H NMR, IR, UV-visible) and also thermal analysis (TG and DTG) techniques. The molar conductance reveals that all the isolated complexes are non-electrolytes. IR spectra suggest that the H₂FH behaves in a monodentate, bidentate and/or tetradentate manner. The electronic spectra of the complexes as well as their magnetic moments suggest octahedral geometries for all isolated complexes except Pd(II) complex has square planner geometry. The kinetic and thermodynamic parameters for the different decomposition steps in the [Cu(H₂FH)Cl₂]路2H₂O, [Cu(FH)(H₂O)₂]路H₂O and [Zn(FH)(H₂O)₂]路H₂O complexes were calculated using the Coats-Redfern equation. Also, the formation constants of complexes in solution was studied pH-metrically. Moreover, the antimicrobial activities of all compounds were studied using a wide spectrum of bacterial and fungal strains.