Four component reaction of aldehydes, isocyanides, Me₃SiN₃, and aliphatic alcohols catalyzed by indium triflate

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• 作者：Hikaru Yanai ; ^{yanai@toyaku.ac.jp} ; Takuji Sakiyama ; Tomoko Oguchi ; Takeo Taguchi ; ^{taguchi@toyaku.ac.jp}
• 关键词：Indium triflate ; Multi-component reaction ; Isocyanide ; Tetrazole
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：20 June, 2012
• 卷：53
• 期：25
• 页码：3161-3164
• 文件大小：416 K

摘要

In the presence of catalytic amount of indium(III) Lewis acids, the four component reaction of aldehydes, isocyanides, trimethylsilyl azide and aliphatic alcohols smoothly proceeded to give alkoxylated 1H-tetrazole products in good yields. In particular, In(OTf)₃ and In(ONf)₃ showed notably high level of catalytic activity in this reaction.