An efficient, expeditious, and diastereoselective one-pot pseudo-five-component reaction for the synthesis of new bis-Betti bases under catalyst-free conditions
- 作者：Mehdi Shafiee ; Ahmad R. Khosropour ; khosropour@chem.ui.ac.ir ; Iraj Mohammadpoor-Baltork ; imbaltor@sci.ui.ac.ir ; Majid Moghadam ; Shahram Tangestaninejad ; Valiollah Mirkhani
- 关键词：Bis-Betti base ; Condensation ; Multi-component reaction ; Aldehydes ; 3-Amino-5-methylisoxazole ; Dihydroxynaphthalene
- 刊名：Tetrahedron Letters
- 出版年：2012
- 期刊代码：109_00404039
- 类别：ch
- 出版时间：13 June, 2012
- 卷：53
- 期：24
- 页码：3086-3090
- 文件大小：1417 K
摘要
A novel, diastereoselective, one-pot synthesis of new bis-Betti bases via condensation of dihydroxynaphthalene, two equivalents of aryl aldehydes, and two equivalents of 3-amino-5-methylisoxazole is reported. Conversion into the adducts was almost quantitative without the use of solvent or catalyst. The reaction conditions are very simple and enable easy isolation of the product.