Catalyst-free synthesis of N-rich heterocycles via multi-component reactions

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• 作者：Zeinab Noroozi Tisseh^a ; Minoo Dabiri^a ; ; Mohsen Nobahar^a ; Ali Abolhasani Soorki^b ; Ayoob Bazgir^a ; ^{a_bazgir@sbu.ac.ir}
• 关键词：Tetrazole ; Pyrazine ; Multi-component ; Azide
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：22 April, 2012
• 卷：68
• 期：16
• 页码：3351-3356
• 文件大小：621 K

摘要

Efficient and straightforward methods for the synthesis of 5-substituted 1H-tetrazoles via multi-component reaction of 伪-dicarbonyl compounds, 2,3-diaminomaleonitrile and sodium azide without any catalyst has been reported. These general protocols provide a wide variety of N-rich heterocyclic compounds (1H-tetrazole-5-yl) pyrazines and di(1H-tetrazole-5-yl) pyrazines, in good to excellent yields.