Comparison of the cytotoxic responses of Escherichia coli (E. coli) AMC 198 to different fullerene suspensions (nC₆₀)

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• 作者：Ji Dai^a ; Chao Wang^a ; Chii Shang^a ; Nigel Graham^b ; Guang-Hao Chen^a ; ^{ceghchen@ust.hk}
• 关键词：nC60 ; Cytotoxicity ; EC50 ; Cytoprotection
• 刊名：Chemosphere
• 出版年：2012
• 期刊代码：15_00456535
• 类别：env
• 出版时间：April, 2012
• 卷：87
• 期：4
• 页码：362-368
• 文件大小：1523 K

摘要

Fullerenes are set to be produced on an industrial scale in anticipation of their wide applications. This calls for research on their environmental and health impacts. This study investigates and compares the cell toxicity of different aqueous fullerene aggregates. Popular C₆₀ dispersal methods were used to prepare four types of nC₆₀ aggregates. These aggregates were tested against the indicator species Escherichia coli (E. coli) AMC 198. With aggregates of around 150 nm in diameter, the THF/nC₆₀ suspension was very toxic and gave rise to a half maximal effective concentration (EC₅₀) of 0.54 mg L^鈭? in E. coli. By contrast, the Tol/nC₆₀ suspension exhibited a cytoprotective role while the Aqu-N₂/nC₆₀ and Aqu-O₂/nC₆₀ suspensions enhanced the metabolism of E. coli. Although some toxicants, such as THF and THF-peroxide, were introduced into the THF/nC₆₀ suspension during the dispersion, the toxicity of nC₆₀ itself cannot be neglected.