Diffusion tensor studies dissociated two fronto-temporal pathways in the human memory system
- 作者：Emi Takahashi ; Kenichi Ohki ; Dae-Shik Kim
- 关键词：Functional magnetic resonance imaging ; Diffusion tensor imaging ; Long-term memory ; Prefrontal cortex ; Temporal cortex ; Connection
- 刊名：NeuroImage
- 出版年：2007
- 期刊代码：83_10538119
- 类别：neu
- 出版时间：15 January 2007
- 卷：34
- 期：2
- 页码：827-838
- 文件大小：1160 K
摘要
Recent functional neuroimaging studies have shown that multiple cortical areas are involved in memory encoding and retrieval. However, the underlying anatomical connections among these memory-related areas in humans remain elusive due to methodological limitations. Diffusion tensor imaging (DTI) is a technique based on detecting the diffusion of water molecules from magnetic resonance images. DTI allows non-invasive mapping of anatomical connections and gives a comprehensive picture of connectivity throughout the entire brain. By combining functional magnetic resonance imaging (fMRI) and DTI, we show that memory-related areas in the left dorsolateral prefrontal cortex (DLPFC) and the left ventrolateral prefrontal cortex (VLPFC) each connect with memory-related areas in the left temporal cortex. This result suggests there are two pathways between prefrontal cortex and temporal cortex related to the human memory system.