An acoustic glucose sensor
- 作者：Ruifen Hu ; Adrian C. Stevenson ; Christopher R. Lowe ; crl1@biotech.cam.ac.uk
- 关键词：Magnetic acoustic resonator sensor ; Glucose monitor ; Viscoelastic change
- 刊名：Biosensors and Bioelectronics
- 出版年：2012
- 期刊代码：12_09565663
- 类别：ch
- 出版时间：15 May, 2012
- 卷：35
- 期：1
- 页码：425-428
- 文件大小：325 K
摘要
In vivo glucose monitoring is required for tighter glycaemic control. This report describes a new approach to construct a miniature implantable device based on a magnetic acoustic resonance sensor (MARS). A 鈭?00-800 nm thick glucose-responsive poly(acrylamide-co-3-acrylamidophenylboronic acid) (poly(acrylamide-co-3-APB)) film was polymerised on the quartz disc (12 mm in diameter and 0.25 mm thick) of the MARS. The swelling/shrinking of the polymer film induced by the glucose binding to the phenylboronate caused changes in the resonance amplitude of the quartz disc in the MARS. A linear relationship between the response of the MARS and the glucose concentration in the range 鈭?-15 mM was observed, with the optimum response of the MARS sensor being obtained when the polymer films contained 鈭?0 mol%3-APB. The MARS glucose sensor also functioned under flow conditions (9 渭l/min) with a response almost identical to the sensor under static or non-flow conditions. The results suggest that the MARS could offer a promising strategy for developing a small subcutaneously implanted continuous glucose monitor.