• 作者：Luis Alejandro Pé ; rez De Llano^a ; ^{eremos26@hotmail.com} ; Francisco Carballada Gonzá ; lez^b ; Olalla Castro Añ ; ó ; n^a ; Marlies Pizarro Perea^c ; Manuel Vá ; zquez Caruncho^d ; Adolfo Baloira Villar^e ; Proyecto Camaron (Control del Asma Mediante el Aná ; lisis Regular del Ó ; xido N&iacute ; trico)
• 关键词：Asma ; Test de control del asma ; Fracció ; n exhalada de ó ; xido n&iacute ; trico ; Asma de control dif&iacute ; cil
• 刊名：Archivos de Bronconeumolog铆a
• 出版年：2010
• 期刊代码：pca65_03002896
• 类别：med
• 出版时间：October 2010
• 卷：46
• 期：10
• 页码：508-513
• 文件大小：234 K

Introduction

The coexistence of potentially aggravating processes is common in asthmatics, particularly in patients with difficult control.

The primary aim of this study is to ascertain whether comorbidity id more common in uncontrolled patients. As a secondary aim, we propose to evaluate the correlation between the asthma control test (ACT) and the fraction of exhaled nitric oxide (FENO).

Patient and methods

A prospective, observational study comparing the function and clinical picture of two groups of asthmatics: controlled (ACT鈮?0) and uncontrolled (ACT<20). They were all assessed for, smoking, rhinosinusitis, obesity, anxiety, depression, vocal cord dysfunction, gastro-oesophageal reflux (GORD), allergic bronchopulmonary aspergillosis (ABPA), COPD and nasal polyps.

Results

A total of 50 patients with controlled asthma and 102 with suboptimal control were included. The patients with an ACT鈮?0 had better lung function, less variation in PEF, less bronchial hyper-reactivity and lower FENO values.

Comorbidities were found in 95%of the controlled asthmatics and in 97%of the uncontrolled. Only the presence of nasal polyps, GORD and ABPA was more frequent in the uncontrolled group. However, the simultaneous presence of 3 or more comorbidity factors was significantly more frequent in patients with sub-optimal control (P=0.01).

There was no significant correlation between the FENO and the ACT values (rho=鈭?.08; P=0.32).

Conclusions

Aggravating comorbidities are more common in patients with sub-optimal control. There was no correlation between the FENO and the ACT values.