• 作者：M. Navarro Merino^a ; ^{mnavarro1@us.es} ; A. André ; s Martí ; n^b ; O. Asensio de la Cruz^c ; M.L. Garcí ; a Garcí ; a^d ; S. Liñ ; á ; n Cortes^e ; J.R. Villa Asensi^f ; en representació ; n del Grupo de Trabajo Asma Infantil de la Sociedad Espa&ntilde ; ola de Neumolog&iacute ; a Pediá ; trica
• 关键词：Asma infantil ; Asma de control dif&iacute ; cil ; Asma grave
• 刊名：Anales de Pediatr铆a
• 出版年：2009
• 期刊代码：pca47_16954033
• 类别：med
• 出版时间：December 2009
• 卷：71
• 期：6
• 页码：548-567
• 文件大小：713 K

Children suffering from difficult-to-control asthma (DCA) require frequent appointments with their physician, complex treatment regimes and often admissions to hospital. Less than 5%of the asthmatic population suffer this condition. DCA must be correctly characterised to rule out false causes of DCA and requires making a differential diagnosis from pathologies that mimic asthma, comorbidity, environmental and psychological factors, and analysing the factors to determine poor treatment compliance. In true DCA cases, inflammation studies (exhaled nitric oxide, induced sputum, broncho-alveolar lavage and bronchial biopsy), pulmonary function and other clinical aspects can classify DCA into different phenotypes which could make therapeutic decision-making easier.