Adiponectin - An independent marker of coronary artery disease occurrence rather than a degree of its advancement in comparison to the IMT values in peripheral arteries

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• 作者：A. Lisowska^a ; ^{anlila@poczta.onet.pl} ; A. Tycinska^a ; M. Knapp^a ; R. Sawicki^a ; P. Lisowski^b ; W.J. Musia艂^a ; S. Dobrzycki^c
• 关键词：Adiponectin ; Intima-media thickness ; Coronary artery disease
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 期刊代码：54_00098981
• 类别：med
• 出版时间：11 April, 2012
• 卷：413
• 期：7-8
• 页码：749-752
• 文件大小：415 K

摘要

Objective

The aim of the study was to establish whether adiponectin may act as an independent risk factor of coronary artery disease (CAD) and if adiponectin has potential relations with a new marker of cardiovascular risk -intima-media thickness (IMT).

Methods

165 patients, who had undergone coronary angiography due to symptoms of CAD were enrolled. Selected clinical and biochemical risk factors were assessed, adiponectin concentrations and IMT were measured.

Results

A significantly lower adiponectin concentrations in the CAD group, as compared to the controls, were found. Adiponectin concentration did not correlate with a degree of coronary vessels changes advancement. No correlation between adiponectin concentrations and IMT values in the studied peripheral arteries were found. The value of 9.8ug/ml has been assigned as a cut-off value. Adiponectin concentrations < 9.8 渭g/ml had the highest positive predictive value (PPV = 95.7%) and specificity (90.9), but low sensitivity (30.8). In the multilogistic regression analysis significant variables influencing the appearance of CAD were found: HDL-C (p = 0.011, OR = 0.88, 95%CI 0.80-0.97), IMT in CCA (p = 0.0048, OR = 5.25, 95%CI 1.65-16.75), IMT in CFA (p = 0.015, OR = 1.65, 95%CI 1.10-2.48 ), and adiponectin concentration < 9.8 渭g/ml (p = 0.032, OR = 28.95, 95%CI 1.31-641.48).

Conclusions

Adiponectin is an independent risk factor of coronary artery disease occurrence, but not its advancement. No correlation between adiponectin concentration and IMT values in peripheral arteries was shown.