Equivalent dipol-generators of electrical brain activity in psychiatric diseases
- 作者：Maurer ; K. ; Dierks ; T.
- 刊名：Biological Psychiatry
- 出版年：1997
- 期刊代码：34_00063223
- 类别：med
- 出版时间：July 1, 1997
- 卷：42
- 期：1, Supplement 1
- 页码：63S
- 文件大小：156 K
摘要
Imaging procedures are steadily gaining importance in psychiatric research. The morphology of the brain can be visualized by means of CT and MRI while cerebral blood flow and the cerebral metabolic state can be evaluated by PET. Neurophysiological methods not only have the advantage of being readily available in a clinical setting, but by now have reached a stage of allowing the estimation of intracerebral generators of electrical activity of the brain. In psychiatric diseases where alteration of background activity is of interest, the method of FFT-approximation allows the estimation of intracerebral EEG-generators in the frequency domain. In the present study we investigated 22 schizophrenic, 22 depressive and 22 patients with dementia of Alzheimer type. In comparison to controls schizophrenic patients showed more anterior and superficial equivalent-dipoles in the beta-bands and a tendency of increased beta-activity was found. With increasing severity of schizophrenic symptoms, the equivalent-dipole in the betal-band was localized more anteriorly and the dipole in the theta-band was localized more inferiorly. Depressed patients demonstrated a significantly divergent pattern of localization between frequency-bands in the anterior-posterior direction. DAT-patients had higher magnitudes in the slow frequency range, correlating with the severity of dementia, and lower ones in the alpha- and beta-range. Furthermore, in DAT patients, a shift of alpha- and beta-activity towards frontal brain regions was observed. The amount of this shift correlated with the degree of dementia. These new developments may allow a physiological interpretation of results of neurophysiological investigations similar to other functional imaging methods.