Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists

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• 作者：Palin ; Ronald ; Barn ; David R. ; Clark ; John K. ; Cottney ; Jean E. ; Cowley ; Phillip M. ; Crockatt ; Marc ; et. al.
• 关键词：ORL1 ; Nociception ; Opioid ; Analgesia
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2005
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：February 1, 2005
• 卷：15
• 期：3
• 页码：589-593
• 文件大小：267 K

摘要

A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure芒芒芒activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.