Supercritical fluid simulated moving bed chromatography for the separation of ethyl linoleate and ethyl oleate

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• 作者：Carlos André ; s Martí ; nez Cristancho^a ; ^{cristancho@mpi-magdeburg.mpg.de} ; Stephanie Peper^b ; Monika Johannsen^a
• 关键词：Simulated moving bed chromatography (SMB) ; Supercritical fluid chromatography (SFC) ; Fatty acid ethyl esters ; Linear adsorption coefficient
• 刊名：The Journal of Supercritical Fluids
• 出版年：2012
• 期刊代码：60_08968446
• 类别：ce
• 出版时间：June, 2012
• 卷：66
• 期：Complete
• 页码：129-136
• 文件大小：667 K

摘要

Supercritical fluid-simulated moving bed (SF-SMB) chromatography is an attractive technology thanks to the outstanding performance of continuous countercurrent adsorption processes in combination with the tunability of eluent strength of supercritical CO₂. This work focuses on the process development steps of simulated moving bed chromatography for the separation of ethyl linoleate and ethyl oleate on silica gel using supercritical carbon dioxide under linear conditions. Adsorption isotherms of the components of interest were determined at analytical scale and applied together with the equilibrium theory for the design of a two-step SF-SMB process for the separation of the fatty acid ethyl esters. Results of the experimental validation of the continuous chromatographic separation of ethyl linoleate and ethyl oleate are shown and discussed in detail.