Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice

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• 作者：Peter A. Groblewski ; ^{pgroblew@uw.edu} ; Christopher L. Cunningham
• 关键词：Extinction ; mPFC ; CPP ; Ethanol ; Mice ; Intra-cranial
• 刊名：Behavioural Brain Research
• 出版年：2012
• 期刊代码：3_01664328
• 类别：neu
• 出版时间：21 April, 2012
• 卷：230
• 期：1
• 页码：299-303
• 文件大小：525 K

摘要

The medial prefrontal cortex (mPFC) is important for extinction of many behaviors including conditioned place preference (CPP). We examined the effects of intra-mPFC inactivation (with bupivacaine) on extinction of ethanol-induced CPP in mice. Injections of both bupivacaine and vehicle impaired extinction whereas no-surgery control mice extinguished normally. Consistent with recently reported effects of mPFC lesions, these data suggest that extinction was impaired by excessive mPFC damage induced by repeated intracranial infusions.