The evolution of Trypanosoma cruzi: the 鈥榖at seeding鈥?hypothesis

详细信息	查看全文 | 推荐本文 |

• 作者：Patrick B. Hamilton¹ ; Marta M.G. Teixeira² ; Jamie R. Stevens¹ ; ^{J.R.Stevens@exeter.ac.uk} ; ^{j.r.stevens@ex.ac.uk}
• 关键词：Trypanosoma cruzi cruzi ; parasite evolution ; Gondwana ; genetic diversity ; bat trypanosomes ; Chagas disease ; Kinetoplastid ; biogeography
• 刊名：Trends in Parasitology
• 出版年：2012
• 期刊代码：87_14714922
• 类别：imm
• 出版时间：April, 2012
• 卷：28
• 期：4
• 页码：136-141
• 文件大小：561 K

摘要

Recent discussions on the evolution of Trypanosoma cruzi have been dominated by the southern super-continent hypothesis, whereby T. cruzi and related parasites evolved in isolation in the mammals of South America, Antarctica and Australia. Here, we consider recent molecular evidence suggesting that T. cruzi evolved from within a broader clade of bat trypanosomes, and that bat trypanosomes have successfully made the switch into other mammalian hosts in both the New and Old Worlds. Accordingly, we propose an alternative hypothesis - the bat seeding hypothesis - whereby lineages of bat trypanosomes have switched into terrestrial mammals, thereby seeding the terrestrial lineages within the clade. One key implication of this finding is that T. cruzi may have evolved considerably more recently than previously envisaged.