- 作者：Armando Pé ; rez de Prado ; aperez@secardiologia.es ; Claudia Pé ; rez-Martí ; nez ; Carlos Cuellas-Ramó ; n ; José ; M. Gonzalo-Orden ; Marta Regueiro-Purriñ ; os ; Beatriz Martí ; nez-Ferná ; ndez ; Alejandro Diego-Nieto ; Felipe Ferná ; ndez-Vá ; zquez
- 关键词：Inflamació ; n ; Endotelio ; Stent coronario ; Microscopio electró ; nico de barrido ; Modelo animal
- 刊名：Revista Espa帽ola de Cardiolog铆a
- 出版年：2011
- 期刊代码：pca308_03008932
- 类别：med
- 出版时间：February 2011
- 卷：64
- 期：2
- 页码：159-162
- 文件大小：537 K
There is histological evidence that drug-eluting stents are associated with delayed endothelialization and a persistent inflammatory state. Moreover, clusters of inflammatory cells have been observed on luminal surfaces by scanning electron microscopy. With the aim of quantifying this inflammatory response, we implanted one bare-metal stent and two drug-eluting stents containing different doses of vinblastine embedded in the same polymer into the coronary arteries of 12 domestic pigs. The density of inflammatory cells in a representative area (100聽x聽100聽渭m) was quantified at 3 and 7 days. Endothelialization was more complete in bare-metal stents than in drug-eluting stents at both 3 days (P = .016) and 7 days (P = .0001). The degree of inflammation induced by the drug-eluting stents was higher than that induced by the bare-metal stents at both 3 days (11.8 卤 3.5%vs. 4.5 卤 2%; P = .001) and 7 days (26.3 卤 4.4%vs. 1.2 卤 1.5%; P = .0001). In addition, the time sequence was inverted: the inflammatory response increased over time with the drug-eluting stents, while the opposite occurred with the bare-metal stents.
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