Curcumin-loaded 纬-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma

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• 作者：Santosh S. Dhule ; MS^a ; ^b ; Patrice Penfornis ; MS^b ; Trivia Frazier ; BS^b ; Ryan Walker ; BS^b ; Joshua Feldman ; BS^b ; Grace Tan ; PhD^a ; Jibao He ; PhD^c ; Alina Alb ; PhD^d ; Vijay John ; DEngSc^a ; Radhika Pochampally ; PhD^b ; ^e ; ^{rpocham@tulane.edu}
• 关键词：Apoptosis ; Autophagy ; Curcumin ; Cyclodextrin ; Liposome ; Osteosarcoma
• 刊名：Nanomedicine ; Nanotechnology ; Biology and Medicine
• 出版年：2012
• 期刊代码：11_15499634
• 类别：et
• 出版时间：May, 2012
• 卷：8
• 期：4
• 页码：440-451
• 文件大小：2075 K

摘要

The delivery of curcumin, a broad-spectrum anticancer drug, has been explored in the form of liposomal nanoparticles to treat osteosarcoma (OS). Curcumin is water insoluble and an effective delivery route is through encapsulation in cyclodextrins followed by a second encapsulation in liposomes. Liposomal curcumin's potential was evaluated against cancer models of mesenchymal (OS) and epithelial origin (breast cancer). The resulting 2-Hydroxypropyl-纬-cyclodextrin/curcumin - liposome complex shows promising anticancer potential both in vitro and in vivo against KHOS OS cell line and MCF-7 breast cancer cell line. An interesting aspect is that liposomal curcumin initiates the caspase cascade that leads to apoptotic cell death in vitro in comparison with DMSO-curcumin induced autophagic cell death. In addition, the efficiency of the liposomal curcumin formulation was confirmed in vivo using a xenograft OS model. Curcumin-loaded 纬-cyclodextrin liposomes indicate significant potential as delivery vehicles for the treatment of cancers of different tissue origin.

From the Clinical Editor

Curcumin-loaded 纬-cyclodextrin liposomes were demonstrated in vitro to have significant potential as delivery vehicles for the treatment of cancers of mesenchymal and epithelial origin. Differences between mechanisms of cell death were also evaluated.