Synthesis and thermal cyclization of an enediyne-sulfonamide

详细信息	查看全文 | 推荐本文 |

• 作者：Klein ; Michael ; Kö ; nig ; Burkhard
• 关键词：Enediyne ; Yne-amine ; Carbene rearrangement ; Thermal cyclization
• 刊名：Tetrahedron
• 出版年：2004
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：January 26, 2004
• 卷：60
• 期：5
• 页码：1087-1092
• 文件大小：188 K

摘要

The synthesis of an enediyne sulfonamide by alkylidene carbene rearrangement is reported. The compound cyclizes thermally to give the Bergman product, which was prepared independently for comparison. Like other σ-acceptor substituents at the enediyne alkyne termini, such as fluoride, oxonium or ammonium groups, the sulfonamide moiety enhances the reactivity for thermal Bergman cyclization as shown by the cyclization kinetic of the title compound.