Cyclooxygenase inhibitory activity of ginsenosides from heat-processed ginseng

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• 作者：Hye Hyun Yoo^a ; Jeong Hill Park^b ; ^{hillpark@snu.ac.kr}
• 关键词：Heat-processed ginseng ; Ginsenoside ; Cyclooxygenase-1 ; Cyclooxygenase-2
• 刊名：Food Chemistry
• 出版年：2012
• 期刊代码：48_03088146
• 类别：abs
• 出版时间：1 August, 2012
• 卷：133
• 期：3
• 页码：998-1000
• 文件大小：174 K

摘要

Ginsenosides, from heat-processed ginseng, and sapogenins were evaluated for their inhibitory effects on the enzyme catalytic activities of cyclooxygenases-1 and -2 (COX-1 and -2). The ginsenosides, 20(S)-Rg₃, Rg₅, and Rk₁, inhibited COX-2 activity, but did not affect the enzyme activity of COX-1. Protopanaxatriol (PPT) moderately inhibited both COX-1 and -2. The ginsenosides, 20(R)-Rg₃, Re, and protopanaxadiol (PPD) showed a minimal effect on COX-1 and -2 activities. Taken together, ginsenosides Rg₃ (20S-form), Rg₅ and Rk₁ showed selective inhibitory activity on COX-2 by behaving as an inhibitor of the enzyme-substrate reaction.