Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells

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• 作者：M. Nagaraju^a ; E. Gnana Deepthi^a ; C. Ashwini^a ; M.V.P.S. Vishnuvardhan^b ; V. Lakshma Nayak^b ; Rajesh Chandra^a ; S. Ramakrishna^b ; B.B. Gawali^a ; ^{gawalibb@yahoo.co.in}
• 关键词：Cytotoxic activity ; Hybrid chalcones ; Claisen rearrangement ; Claisen&ndash ; Schmidt condensation
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 July, 2012
• 卷：22
• 期：13
• 页码：4314-4317
• 文件大小：544 K

摘要

A new class of hybrid chalcones (17a-l & 18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by ¹H NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate cancer), HT-29 (colon cancer), B-16 (mouse macrophages) and NCI-H460 (lung cancer) cell lines. Three compounds 18i, 18j and 18l (IC₅₀ = 8.4, 7.9 & 5.9 渭M) showed significant activity against PC-3 cell line.