Therapy-related myelodysplastic syndrome and acute myeloid leukemia following treatment of acute myeloid leukemia: Possible role of cytarabine
- 作者：Cecilia Arana-Yi ; AnneMarie W. Block ; Sheila N. Sait ; Laurie A. Ford ; Maurice Barcos ; Maria R. Baer
- 关键词：Acute myeloid leukemia ; Myelodysplastic syndrome ; Therapy-related ; Cytarabine
- 刊名：Leukemia Research
- 出版年：2008
- 期刊代码：186_01452126
- 类别：med
- 出版时间：July 2008
- 卷：32
- 期：7
- 页码：1043-1048
- 文件大小：330 K
摘要
Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/t-AML) have been reported only rarely following treatment of AML. We report five patients treated for de novo AML who developed t-MDS/t-AML, all with chromosome 7 abnormalities, including −7, del(7)(q22q36) and del(7)(p11.22p22). All had been treated with cytarabine, topoisomerase 2 inhibitors and granulocyte or granulocyte-monocyte colony-stimulating factor and three with alkylating agents as part of autologous transplant regimens. These cases further document t-MDS/t-AML as a complication of therapy for AML. Presence of chromosome 7 abnormalities in patients with and without prior alkylating agent therapy suggests possible association with the antimetabolite cytarabine.