CD8 T cell defect of TNF-伪 and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection

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• 作者：Megan J. Welch^a ; John R. Teijaro^a ; Hanna A. Lewicki^a ; Marco Colonna^b ; Michael B.A. Oldstone^a ; ^{mbaobo@scripps.edu}
• 关键词：DNAM-1 deficiency ; Acute LCMV infection ; Persistent LCMV infection ; T cell defects
• 刊名：Virology
• 出版年：2012
• 期刊代码：108_00426822
• 类别：imm
• 出版时间：1 August, 2012
• 卷：429
• 期：2
• 页码：163-170
• 文件大小：755 K

摘要

DNAM-1 gene-deficient (鈭?鈭? mice take significantly longer to clear an acute and persistent LCMV infection in vivo than DNAM-1 +/+ mice. During acute LCMV priming, at the single cell level, DNAM-1 鈭?鈭?mice made significantly less cytoplasmic CD8 TNF-伪 and IL-2 but not IFN-纬 than their DNAM-1 +/+ counterparts. Restimulated immune memory CD8 T cells from DNAM-1 鈭?鈭?and DNAM-1 +/+ mice were equivalent in cytolytic activity against LCMV-infected target cells but DNAM-1 鈭?鈭?CD8 T cells had significant reductions in TNF-伪 and IL-2 that were associated on adoptive transfer with the inability to terminate the persistent viral infection.