The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story
- 作者：Thomas ; Matthew L
- 关键词：ICAM-1 intercellular adhesion molecule 1 ; LFA-1 leucocyte functional antigen 1 ; SH Src homology
- 刊名：Current Opinion in Immunology
- 出版年：1999
- 期刊代码：24_09527915
- 类别：imm
- 出版时间：June, 1999
- 卷：11
- 期：3
- 页码：270-276
- 文件大小：642 K
摘要
Antigen-receptor signaling requires Src-family kinases to initiate tyrosine phosphorylation. CD45 dephosphorylates the inhibitory site in Src-family kinases before antigen-receptor engagement and thus serves to ‘prime’ the kinases. It has been unclear why CD45 does not also dephosphorylate ‘activated’ kinases or motifs within the cytoplasmic domains of antigen-receptors and thus prevent signal transduction. Recent reports raise the possibility that CD45 is excluded from engaged antigen-receptors by mechanisms that may include the formation of lipid microdomains.