Cytotoxic activity of some glycoconjugates including saponins and anthracyclines

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• 作者：Filip S. Ekholm^a ; Á ; gnes Beré ; nyi^b ; Lucas Lagerquist^a ; Tiina Saloranta^a ; Istvá ; n Zupkó ; ^b ; Gyula Schneider^c ; Já ; nos Wö ; lfling^c ; Reko Leino^a ; ^{reko.leino@abo.fi}
• 关键词：Anthracyclines ; Cytotoxic activity ; Glycoconjugates ; Saponins
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：15 July, 2012
• 卷：356
• 期：Complete
• 页码：295-298
• 文件大小：323 K

摘要

Many different glycoconjugates, including saponins (e.g., hellebrin) and anthracyclines (e.g., doxorubicin), are known to display cytotoxic activities. In recent work, we have developed synthetic protocols for the synthesis of various glycoconjugates, focusing on glycosylation methods for different classes of biomolecules. Simultaneously a number of saponins and anthracyclines have been generated. In this note, the cytotoxic activities of these synthesized compounds are briefly addressed.