Cytotoxic activity of five limonoids from Meliae cortex and their structure-activity relationship

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• 作者：Zhi-Peng DENG^螖 ; Shao-Chao LIU^螖 ; Shu-Xiang CUI ; Ling ZHOU ; Qing-Qiang YAO ; ^{yqingqiang@yahoo.com}
• 关键词：Limonoids ; Meliae cortex ; Cytotoxic activity ; Structure-activity relation
• 刊名：Chinese Journal of Natural Medicines
• 出版年：2012
• 期刊代码：P72_18755364
• 类别：med
• 出版时间：May, 2012
• 卷：10
• 期：3
• 页码：238-240
• 文件大小：160 K

摘要

Aim

To investigate the cytotoxic activity of five limonoids (1-5) and illuminate their structure-activity relationship (SAR).

Methods

Compounds 1-5 isolated from Meliae cortex were examined for their cytotoxic activity against three cancer cell lines in vitro by MTT method.

Results

Among the tested compounds, all compounds possessed their potent antitumor activity. Especially compound 1 was the most active compound against human liver cancer BEL7402 cells (IC₅₀ 8.57 渭g路mL^鈭?), human lung cancer H460 cells (IC₅₀ 6.29 渭g路mL^鈭?), human stomach cancer SGC-7901 cells (IC₅₀ 6.08 渭g路mL^鈭?).

Conclusion

The SAR of compounds 1-5 indicated that 16-OH was very important for keeping the cytotoxic activity of limonoids.