A binuclear chloride bridged copper(II) complex with a modified ligand structure and different coordination environment and mononuclear cobalt(II) complexes with a pyridylpyrazole ligand: Synthesis, structure and cytotoxic activity

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• 作者：Sujit B. Kumar^a ; ^{sujit_baran@yahoo.com} ; Zala Mahendrasinh^a ; Solanki Ankita^a ; Rangrez Mohammedayaz^b ; Parikh Pragna^b ; E. Suresh^c
• 关键词：Binuclear Cu(II) complex ; Mononuclear cobalt(II) complexes ; Chloride bridge ; Crystal structure ; Different coordination environment ; Cytotoxic activity
• 刊名：Polyhedron
• 出版年：2012
• 期刊代码：87_02775387
• 类别：ch
• 出版时间：4 April, 2012
• 卷：36
• 期：1
• 页码：15-20
• 文件大小：380 K

摘要

One new binuclear chloride bridged copper(II) complex [L鈥?Cl)Cu-(渭-Cl)-Cu(pz)L鈥瞉(PF₆)₂ (1) and two mononuclear cobalt(II) complexes [Co(Cl)L]BF₄路1/2CH₃OH (2) and [Co(Cl)L]PF₆ (3) where L = {N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)}(2-aminomethyl)pyridine, L鈥?#xA0;= {N-(3,5-dimethylpyrazol-1-ylmethyl)}(2-aminomethyl)pyridine and pz = 3,5-dimethyl-pyrazole have been synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction studies. The crystal structure of the binuclear copper(II) complex [L鈥?Cl)Cu-(渭-Cl)-Cu(pz)L鈥瞉(PF₆)₂ shows that the two square plane copper(II) moieties are joined through a single chloride (渭-Cl) bridge and the coordination environment around the two copper atoms are different, whereas the cobalt ion in [Co(Cl)L]BF₄路1/2CH₃OH has a trigonal bipyramidal geometry. The cytotoxic activity of the ligand, and the copper and cobalt complexes 1 and 2 were measured in vitro against the human lymphocyte HL-60 and it shows that the metal complexes have different cytotoxic activities to the organic ligand.