Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole

详细信息	查看全文 | 推荐本文 |

• 作者：Xiao-Dong Yang^a ; ^{xdyang@ynu.edu.cn} ; Wei-Chao Wan^a ; Xiao-Yan Deng^a ; Yan Li^b ; ^{liyanb@mail.kib.ac.cn} ; Li-Juan Yang^c ; Liang Li^a ; Hong-Bin Zhang^a
• 关键词：Hybrid compound ; Benzofuran ; Imidazole ; Cytotoxic activities ; Structure&ndash ; activity relationships
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 April, 2012
• 卷：22
• 期：8
• 页码：2726-2729
• 文件大小：283 K

摘要

A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721).