CD19⁺CD1d⁺CD5⁺ B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses

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• 作者：Mingxia Zhang^a ; ¹ ; Xuebao Zheng^b ; ¹ ; Jieyun Zhang^a ; Yuzhen Zhu^b ; Xiuyun Zhu^a ; Haiying Liu^c ; Musheng Zeng^d ; Michael W. Graner^e ; Boping Zhou^a ; ^{Zhoubp@hotmail.com} ; Xinchun Chen^a ; ^{chenxinchun@gmail.com}
• 关键词：Tuberculosis ; CD19+CD1d+CD5+ B cell ; Th17 cell
• 刊名：Cellular Immunology
• 出版年：2012
• 期刊代码：279_00088749
• 类别：med
• 出版时间：2012
• 卷：274
• 期：1-2
• 页码：89-97
• 文件大小：1016 K

摘要

Although the importance of B cells in the host immune response upon Mycobacterium tuberculosis infection has been recognized, a conclusive role for B cells has yet to be determined. In the present study, we found that primary CD19⁺ B cells isolated from patients with tuberculosis significantly inhibited Th17, but not Th1, cell activation. Moreover, the suppressive activity was mediated by a CD19⁺CD1d⁺CD5⁺ B cell population. Notably, patients with tuberculosis were found to have significantly higher frequencies of CD19⁺CD1d⁺CD5⁺ B cells with stronger suppressive activity than such cells from healthy donors. Furthermore, the frequency of CD19⁺CD1d⁺CD5⁺ B cells in peripheral blood was inversely correlated with that of Th17 cells in patients with tuberculosis. This finding that B cells negatively regulate Th17 responses provides a novel mechanism in the regulation of CD4⁺ T cell responses鈥攁side from regulatory T cells鈥攄uring M. tuberculosis infection, which may impact the clinical outcome of tuberculosis.