Tissue response of defined collagen–elastin scaffolds in young and adult rats with special attention to calcification
- 作者：Daamen ; W.F. ; Nillesen ; S.T.M. ; Hafmans ; T. ; Veerkamp ; J.H. ; van Luyn ; M.J.A. ; van Kuppevelt ; T.H.
- 关键词：Biomaterial ; Tissue engineering ; Calcification ; Tissue response ; Biocompatibility
- 刊名：Biomaterials
- 出版年：2005
- 期刊代码：7_01429612
- 类别：ms
- 出版时间：January, 2005
- 卷：26
- 期：1
- 页码：81-92
- 文件大小：1.01 M
摘要
Collagen–elastin scaffolds may be valuable biomaterials for tissue engineering because they combine tensile strength with elasticity. In this study, the tissue response to and the calcification of these scaffolds were evaluated. In particular, the hypothesis was tested that calcification, a common phenomenon in biomaterials, may be due to microfibrils within the elastic fibre, and that these microfibrils might generate a tissue response. Four scaffolds were subcutaneously implanted, viz. collagen, collagen+pure elastin, collagen+microfibril-containing, and collagen+pulverised elastic ligament (the source for elastin). Explants were evaluated at day 3, 7 and 21.