Spontaneous alternation and spatial learning in Dab1^scm (scrambler) mutant mice

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• 作者：C. Jacquelin^a ; C. Strazielle^a ; R. Lalonde^b ; ^{robert.lalonde@univ-rouen.fr}
• 关键词：Reelin ; Cerebellum ; Hippocampus ; Spontaneous alternation ; Morris water maze ; Spatial learning
• 刊名：Brain Research Bulletin
• 出版年：2012
• 期刊代码：9_03619230
• 类别：neu
• 出版时间：10 March, 2012
• 卷：87
• 期：4-5
• 页码：383-386
• 文件大小：389 K

摘要

Homozygous Dab1^scm mutants with cell ectopias in cerebellar cortex, hippocampus, and neocortex were compared with non-ataxic heterozygous and wild-type controls in spontaneous alternation and Morris water maze tests. Although there were no group differences in alternation rates, wild-type and heterozygote groups alternated above chance levels, whereas homozygous Dab1^scm mutants did not. In the Morris water maze, Dab1^scm mutants were impaired in both hidden and visible platform subtests. The deficits in spontaneous alternation and water maze measures reproduce the phenotype previously described in Reln^rl-Orl mutants, attributed to disturbance of the same molecular pathway involving reelin.