Bystander-mediated stimulation of proteolipid protein-specific regulatory T (T_reg) cells confers protection against experimental autoimmune encephalomyelitis (EAE) via TGF-尾

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• 作者：SangMu Jun ; Javier Ochoa-Repá ; raz¹ ; Dagmara Zlotkowska² ; Teri Hoyt ; David W. Pascual ; ^{dpascual@montana.edu}
• 关键词：CFA/I ; colonization factor antigen I ; EAE ; experimental autoimmune encephalomyelitis ; HNLNs ; head and neck lymph nodes ; MS ; multiple sclerosis ; PLP ; proteolipid protein ; Treg cell ; regulatory T cell
• 刊名：Journal of Neuroimmunology
• 出版年：2012
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：April, 2012
• 卷：245
• 期：1-2
• 页码：39-47
• 文件大小：913 K

摘要

To assess the potency of regulatory T (T_reg) cells induced against an irrelevant Ag, mice were orally vaccinated with Salmonella expressing Escherichia coli colonization factor antigen I fimbriae. Isolated CD25⁺ and CD25^{鈭?/sup>CD4+ T cells were adoptively transferred to naive mice, and T_reg cells effectively protected against experimental autoimmune encephalomyelitis (EAE), unlike T_reg cells from Salmonella vector-immunized mice. This protection was abrogated upon in vivo neutralization of TGF-尾, resulting in elevated IL-17 and loss of IL-4 and IL-10 production. Thus, T_reg cells induced to irrelevant Ags offer a novel approach to treat autoimmune diseases independent of auto-Ag.}