R. David Lankes et al., Editors, Virtual Reference Service: From Competencies to Assessment, Neal-Schuman Publishers, Inc., New York (2008) ISBN 1-55570-5286 206 p. $75.00.
- 作者：Justine Alsop-Cotton
- 关键词：Vogt– ; Koyanagi– ; Harada syndrome ; CTLA-4 gene ; Polymorphism
- 刊名：The Journal of Academic Librarianship
- 出版年：2008
- 期刊代码：53_00991333
- 类别：soc
- 出版时间：May 2008
- 卷：34
- 期：3
- 页码：270-271
- 文件大小：62 K
摘要
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a critical negative regulator of the T cell response, has been shown to be associated with a variety of autoimmune diseases. In this study, we investigated the association of CTLA-4 gene polymorphisms (− 1661A/G; − 318C/T; + 49G/A, and CT60) with Vogt–Koyanagi–Harada (VKH) syndrome in Chinese Han patients and normal controls. The results showed that the frequency of the G allele at the + 49 site was significantly higher in VKH patients than that observed in healthy controls (71.6%versus 62.8%, P = 0.0046, Pc = 0.037). Three haplotypes were identified from the four SNPs. The frequency of haplotype − 1661A:− 318C:+ 49G:CT60G, the most prevalent haplotype both in patients and controls, was significantly higher in patients than that in controls (70.1%versus 60.0%, P= 0.0013, n= 16, Pc = 0.021). These results suggest that CTLA-4 genetic polymorphisms are associated with the susceptibility to VKH syndrome.