Synthesis and structure–activity relationship of aminopyrimidine IKK2 inhibitors

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• 作者：Alistair H. Bingham ; Richard J. Davenport ; Richard Fosbeary ; Lewis Gowers ; Rol ; L. Knight ; Christopher Lowe ; David A. Owen ; David M. Parry ; Will R. Pitt
• 关键词：IKK2 ; Aminopyrimidine ; Inflammation ; Kinase
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2008
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 June 2008
• 卷：18
• 期：12
• 页码：3622-3627
• 文件大小：193 K

摘要

The synthesis and structure–activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.