Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice

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• 作者：Francesco Marrosu ; Marco Bortolato ; Roberto Frau ; Marco Orrù ; Monica Puligheddu ; Mauro Fà ; Antonella Muroni ; Antonella Tuveri ; Giampaolo Mereu
• 关键词：Levetiracetam ; DBA/2J mice ; Absence epilepsy
• 刊名：Epilepsy Research
• 出版年：2007
• 期刊代码：87_09201211
• 类别：med
• 出版时间：July 2007
• 卷：75
• 期：2-3
• 页码：224-227
• 文件大小：237 K

摘要

Recent evidence highlights levetiracetam (LEV) as an advantageous treatment of absence epilepsy (AE). Thus, we investigated the effects of this drug in DBA/2J mice, a murine model of AE. Similarly to ethosuximide (200 mg/kg, intraperitoneal, i.p.) and sodium valproate (250 mg/kg, i.p.), two classic antiabsence agents, LEV (50–200 mg/kg, i.p.) reduced the occurrence of spike-and-wave discharges, AE's typical electroencephalographic patterns. Our results confirm LEV's efficacy in AE treatment.