Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis
- 作者：Mamta Rawat ; Chantale Johnson ; Vanessa Cadiz ; Yossef Av-Gay
- 关键词：Mycothiol ; Mycothiol deacetylase ; Mycothiol ligase ; Mycothiol synthase ; Oxidative stress ; Toxins ; Xenobiotics
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2007
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：9 November 2007
- 卷：363
- 期：1
- 页码：71-76
- 文件大小：153 K
摘要
The role of mycothiol in mycobacteria was examined by comparative analysis of mutants disrupted in the four known genes encoding the protein machinery needed for mycothiol biosynthesis. These mutants were sensitive to acid stress, antibiotic stress, alkylating stress, and oxidative stress indicating that mycothiol and mycothiol-dependent enzymes protect the mycobacterial cell against attack from various different types of stresses and toxic agents.