Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)
- 作者：Mohamed H. Ahmed ; Christopher D. Byrne
- 关键词：Double-stranded RNA ; Well-ordered stem-loop ; decoration ; none ; color ; black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml115&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=
- 刊名：Drug Discovery Today
- 出版年：2007
- 期刊代码：29_13596446
- 类别：imm
- 出版时间：September 2007
- 卷：12
- 期：17-18
- 页码：740-747
- 文件大小：943 K
摘要
Recent developments in the study of RNA silencing indicate that double-stranded RNA (dsRNA) can be used in eukaryotes to block expression of a corresponding cellular gene. There is also a large class of small non-coding RNAs having potential to form a distinct, stable stem-loop in numbers of eukaryotic genomes. We had reported that a large imperfect dsRNA structure with hundreds of base-pairs (bp) in the decoration:none; color:black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml109&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=3e9a8afaac0873df053fdb7caad0d4af" title="Click to view the MathML source">3′ untranslated region (decoration:none; color:black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml110&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=707f5610265cc2a17d1849cd2b339ec2" title="Click to view the MathML source">3′UTR) of cytotoxic ribonuclease was correlated with the translation suppression. In this study, we search for such dsRNAs in a decoration:none; color:black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml111&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=8da439670f310ea4335ec0e6c1ec79d2" title="Click to view the MathML source">3′ UTR database. The occurrence rate of large dsRNA in decoration:none; color:black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml112&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=074b9e54131ba8cddbd897b774f69e1b" title="Click to view the MathML source">3′ UTRs ranges from 0.01%in plant to 0.30%in vertebrate mRNAs. However, small imperfect dsRNAs of decoration:none; color:black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml113&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=264cee45c78fc846c0b8d091d56bb53b" title="Click to view the MathML source">
30 bp are much more prevalent than large ones. The small dsRNAs are statistically very significant and uniquely well-ordered. Most of them have the conserved structural features of pre-miRNAs. Our data mining of the dsRNAs in the decoration:none; color:black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml114&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=708116e2017ce1d45f59f40f24a518d4" title="Click to view the MathML source">3′ UTR database can be used to explore RNA-based regulation of gene expression.
30 bp are much more prevalent than large ones. The small dsRNAs are statistically very significant and uniquely well-ordered. Most of them have the conserved structural features of pre-miRNAs. Our data mining of the dsRNAs in the decoration:none; color:black" href="/science?_ob=MathURL&_method=retrieve&_udi=B6VRM-4N5TNHB-2&_mathId=mml114&_user=10&_cdi=6238&_rdoc=12&_acct=C000050221&_version=1&_userid=10&md5=708116e2017ce1d45f59f40f24a518d4" title="Click to view the MathML source">3′ UTR database can be used to explore RNA-based regulation of gene expression.