IFN-gamma and IL-4 production of CD4⁺ T cell subsets in the rat

详细信息	查看全文 | 推荐本文 |

• 作者：Hylkema ; Machteld N. ; van der Deen ; Margaretha ; Pater ; Jennie M. ; van der Meide ; Peter H. ; et. al.
• 刊名：Immunology Letters
• 出版年：1997
• 期刊代码：115_01652478
• 类别：med
• 出版时间：May, 1997
• 卷：56
• 期：1-3
• 页码：421-422
• 文件大小：329 K

摘要

Introduction: Previous studies have shown that CD4⁺/CD45RC⁺ T cells proliferate vigorously in cell-mediated reactivity assays and that these cells produce high levels of IL-2 and IFN-gamma upon activation. CD4⁺/CD45RC⁻ T cells, on the other hand, have been shown to provide B cell help in secondary antibody responses. CD4⁺/RT6⁺ T cells have been associated with the suppression of in vitro or in vivo cell-mediated reactivity and their activity has been associated with IL-4 production. In line with the above and the known properties of CD4⁺/CD45RC⁺/RT6⁻ and CD4⁺/CD45RC⁻/RT6⁺ T cell subsets, we have earlier proposed that these phenotypes may represent Th-1 and Th-2 memory T cells in the rat. In the present study, we analyzed the IFN-gamma and IL-4 production of different T cell subsets.