Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-na茂ve boys with attention deficit hyperactivity disorder

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• 作者：Li Sun^a ; ^b ; Qingjiu Cao^a ; ^b ; Xiangyu Long^c ; Manqiu Sui^a ; ^b ; Xiaohua Cao^a ; ^b ; Chaozhe Zhu^c ; Xinian Zuo^c ; Li An^a ; ^b ; Yan Song^c ; Yufeng Zang^c ; ^{zangyf@gmail.com} ; Yufeng Wang^a ; ^b ; ^{wangyf@bjmu.edu.cn}
• 关键词：ADHD ; Dorsal anterior cingulate cortex ; Default-mode network ; Development ; Resting-state fMRI ; Functional connectivity
• 刊名：Psychiatry Research ; Neuroimaging
• 出版年：2012
• 期刊代码：226_09254927
• 类别：med
• 出版时间：28 February, 2012
• 卷：201
• 期：2
• 页码：120-127
• 文件大小：916 K

摘要

A previous study indicated that adults with attention deficit hyperactivity disorder (ADHD) had a decreased anti-correlation between the dorsal anterior cingulate cortex (dACC) and the default mode network (DMN). In this study, we investigated whether children with ADHD also show a decreased anti-correlation between the dACC and the DMN. We also explored the developmental characteristics of the resting-state functional connectivity (RSFC) of the dACC with the DMN in children with ADHD. Resting-state functional magnetic resonance imaging scans were obtained from a 3T scanner in 19 drug-na茂ve boys with ADHD and 23 controls. Compared with normal controls, the dACC in boys with ADHD showed a significantly decreased negative RSFC with the DMN, including the dorsomedial prefrontal cortex and the posterior cingulate cortex. The RSFC strength between the dACC and the posterior cingulate cortex showed a significantly negative correlation with age in normal controls, but not in boys with ADHD. This decreased anti-correlation may suggest an abnormal balance or interaction between attentional and intrinsic thoughts. Our age-related analysis suggested an abnormal development pattern of the dACC-DMN interaction in ADHD.