Novel malonamide derivatives as potent κ opioid receptor agonists

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• 作者：Guo-Hua Chu ; Minghua Gu ; Joel A. Cassel ; Serge Belanger ; Thomas M. Graczyk ; Robert N. DeHaven ; Nathalie Conway-James ; Michael Koblish ; Patrick J. Little ; Diane L. DeHaven-Hudkins ; et al.
• 关键词：Opioid ; κ ; Agonist ; Analgesic
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 April 2007
• 卷：17
• 期：7
• 页码：1951-1955
• 文件大小：153 K

摘要

A novel series of malonamide derivatives was synthesized. These amides were shown to be potent and selective κ opioid receptor agonists.