Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: Ex vivo and in vivo studies
- 作者：Akbar Bayat ; Farid A. Dorkoosh ; Ahmad Reza Dehpour ; Leila Moezi ; Bagher Larijani ; Hans E. Junginger ; Morteza Rafiee-Tehrani
- 关键词：Chitosan ; Triethyl chitosan ; Dimethylethyl chitosan ; Insulin ; Nanoparticles ; Ex vivo and in vivo studies
- 刊名：International Journal of Pharmaceutics
- 出版年：2008
- 期刊代码：24_03785173
- 类别：pha
- 出版时间：22 May 2008
- 卷：356
- 期：1-2
- 页码：259-266
- 文件大小：514 K
摘要
The aim of the present study was to develop insulin nanoparticulate systems by using chitosan (CS), triethylchitosan (TEC) and dimethyl-ethylchitosan (DMEC, a new quaternized derivative of chitosan) for colon delivery.