Taraxerone enhances alcohol oxidation via increases of alcohol dehyderogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities and gene expressions

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• 作者：Chang-Keun Sung^a ; Seung-Mi Kim^b ; Chang-Jin Oh^a ; Sun-A. Yang^b ; Byung-Hee Han^b ; Eun-Kyoung Mo^b ; ^{ekymo@hanmail.net}
• 关键词：Taraxerone ; Sedum sarmentosum ; Alcohol dehydrogenase (ADH) ; Acetaldehyde dehydrogenase (ALDH) ; Catalase
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：July, 2012
• 卷：50
• 期：7
• 页码：2508-2514
• 文件大小：653 K

摘要

The present study, taraxerone (d-friedoolean-14-en-3-one) was isolated from Sedum sarmentosum with purity 96.383%, and its enhancing effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were determined: EC₅₀ values were 512.42 卤 3.12 and 500.16 卤 3.23 渭M for ADH and ALDH, respectively. In order to obtain more information on taraxerone related with the alcohol metabolism, 40%ethanol (5 mL/kg body weight) with 0.5-1 mM of taraxerone were administered to mice. The plasma alcohol and acetaldehyde concentrations of taraxerone-treated groups were significantly lowered than those of the control group (p < 0.01): approximately 20-67%and 7-57%lowered for plasma alcohol and acetaldehyde, respectively. Compare to the control group, the ADH and ALDH expressions in the liver tissues were abruptly increased in the taraxerone-treated groups after ethanol exposure. In addition, taraxerone prevented catalase, superoxide dismutase, and reduced glutathione concentrations from the decrease induced by ethanol administration with the concentration dependent manner.