Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase

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• 作者：Md. Maniruzzaman Manir^a ; Jeong Kee Kim^b ; Byeong-Gon Lee^b ; Surk-Sik Moon^a ; ^{ssmoon@kongju.ac.kr}
• 关键词：Green tea ; Camellia sinensis ; Theaceae ; Quercetin glycosides ; Camelliquercetisides ; Alcohol dehydrogenase (ADH)
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2012
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：1 April, 2012
• 卷：20
• 期：7
• 页码：2376-2381
• 文件大小：251 K

摘要

Four new quercetin acylglycosides, designated camelliquercetisides A-D, quercetin 3-O-[伪-l-arabinopyranosyl(1鈫?)][2-O鈥?em>-(E)-p-coumaroyl][尾-d-glucopyranosyl(1鈫?)-伪-l-rhamnopyranosyl(1鈫?)]-尾-d-glucoside (17), quercetin 3-O-[2-O鈥?(E)-p-coumaroyl][尾-d-glucopyranosyl(1鈫?)-伪-l-rhamnopyranosyl(1鈫?)]-尾-d-glucoside (18), quercetin 3-O-[伪-l-arabinopyranosyl(1鈫?)][2-O鈥?(E)-p-coumaroyl][伪-l-rhamnopyranosyl(1鈫?)]-尾-d-glucoside (19), and quercetin 3-O-[2-O鈥?(E)-p-coumaroyl][伪-l-rhamnopyranosyl(1鈫?)]-尾-d-glucoside (20), together with caffeine and known catechins, and flavonoids (1-16) were isolated from the leaves of Camellia sinensis. Their structures were determined by spectroscopic (1D and 2D NMR, IR, and HR-TOF-MS) and chemical methods. The catechins and flavonoidal glycosides exhibited yeast alcohol dehydrogenase (ADH) inhibitory activities in the range of IC₅₀ 8.0-70.3 渭M, and radical scavenging activities in the range of IC₅₀ 1.5-43.8 渭M, measured by using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.