Simultaneous 2-O-deacetylation and 4-amination of peracetylated Neu5Ac: application to the synthesis of (4→4)-piperazine derivatives linked sialic acid dimers

详细信息	查看全文 | 推荐本文 |

• 作者：Deju Ye ; Guanghui Deng ; Wenfeng Liu ; Yu Zhou ; Enguang Feng ; Hualiang Jiang ; Hong Liu
• 关键词：Condensation heat transfer ; Low fin tube ; CFC11 ; HCFC123 ; Building chillers ; Energy efficiency
• 刊名：Tetrahedron
• 出版年：2008
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：30 June 2008
• 卷：64
• 期：27
• 页码：6544-6550
• 文件大小：711 K

摘要

A simultaneous stereoselective 2-O-deacetylation and 4-amination reaction of peracetylated Neu5Ac 1 has been established with cyclic secondary amines, such as 1-N-Boc-piperazine. Four C₂-symmetric and two asymmetric sialic acid dimers with (4→4)-piperazine derivatives linked were synthesized. They may serve as precursors of unnatural polysialic acids.