Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease
- 作者：Ozturk ; Ayla ; Desai ; Purnima P. ; Minster ; Ryan L. ; DeKosky ; Steven T. ; Kamboh ; M. Ilyas
- 关键词：Alzheimer's disease ; Chromosome 10 ; Haplotype ; Age-at-onset
- 刊名：Neurobiology of Aging
- 出版年：2005
- 期刊代码：202_01974580
- 类别：med
- 出版时间：August - May, 2005
- 卷：26
- 期：8
- 页码：1161-1165
- 文件大小：66.2 K
摘要
Linkage studies suggest the presence of putative risk and/or age-at-onset genes for Alzheimer's disease on Chromosome 10. Recently, a genomic converging approach using a combination of linkage, expression and association studies has reported significant associations of the glutathione S-transferase omega 1 and 2 (GSTO1 and GSTO2) genes and possibly the protease serine 11 (PRSS11) gene on chromosome 10 with age-at-onset, but not risk, for Alzheimer's disease (AD) and Parkinson disease. We investigated the association of the reported three polymorphisms in 990 sporadic late-onset AD cases (26%autopsy confirmed) and 735 controls. In our sample, we found no association either with age-at-onset in AD cases or with disease risk in the case-control cohort. However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD.